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| 2024-04-26 10:26:01 | onclick： | Synthesis of artificial cell stents with DNA |
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Important for regenerative medicine and drug delivery research
In a new study, scientists at the University of North Carolina at Chapel Hill have made a breakthrough in the technology of creating artificial cells that resemble human cells by manipulating DNA and proteins, which are important parts of life.This achievement is of great significance to regenerative medicine, drug delivery and diagnostic tools.The paper was published in the journal Nature Chemistry on the 23rd.
Using this result, the researchers say, it is also possible to develop fabrics or tissues that respond dynamically to environmental changes.
The main components of cells and tissues are proteins that come together to perform various functions and construct biological structures.Proteins are essential for the formation of cell scaffolds.Without cell scaffolds, the structure and function of cells may be affected.
The new study instructs protein building blocks peptides and genetic material to form cell scaffolds together with new programmable peptide-DNA technology without using natural proteins.These cell scaffolds change shape and respond to their surroundings.
The researchers explained that DNA does not normally appear inside the cell scaffold, and they reprogrammed the DNA sequence to become a building material that binds peptides together to form the scaffold.Programming DNA in this way means that scientists can create new cells with specific functions and even fine-tune the cell's response to external stress.Although living cells are more complex than synthetic cells, they are also more susceptible to harsh environments, such as high temperatures.Synthetic cells are stable even at 50°C, opening up the possibility of making cells with extraordinary abilities in environments that are not normally suitable for human life.
The research team believes that this study helps people understand life.Synthetic cell technology not only allows scientists to "replicate" nature's functions, but also to create new materials that go beyond biology, promising major changes in fields such as biotechnology and medicine.
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