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| 2024-04-12 12:39:06 | onclick： | New Weight Loss Drugs |
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In the next few years, two new drugs to treat obesity are expected to be on the market, each with its own unique advantages over the best-selling weight loss drugs on the market today.
The first, called orforglipron, is easier to manufacture and use (orally) and cheaper.The second, called retatrutide, has an unprecedented weight loss effect.The Phase II clinical trials of the two weight loss drugs provided data on the efficacy and ideal dose of the drug in a small group of participants, the results of which were published this month in the New England Journal of Medicine.
Both Orforglipron and Reatrutide simulate hormones produced by the lining of the gut in response to certain nutrients.These hormones help slow the passage of food through the digestive tract and reduce appetite by acting on receptors in the brain, both of which reduce people's cravings for food and thus help lose weight.
These drugs belong to the glucagon-like peptide-1 receptor (GLP-1) agonist class.Over the past five years or so, two GLP-1 receptor agonist drugs that cause significant weight loss have been marketed and attracted a lot of attention.One of the drugs, trizepatide (selling name Mounjaro), has only been approved by U.S. regulators to treat diabetes.Another approved drug, semaglutide, is sold under two brands: Azeempic (a diabetes treatment) and Wegovy (a obesity treatment).
Both Trizepatide and semaglutide can help obese patients reap the life-saving additional benefits of weight loss, such as lowering blood sugar and lowering high blood pressure.Wegovy and Mounjaro need to be injected once a week, which makes many users uncomfortable.What's more, both drugs are polypeptide drugs that are expensive to manufacture and require a lot of labor.If used according to the dose in clinical trials, the two drugs will cost more than $1,000 a month, making it difficult to find drugs when supplies are in short supply.
Orforglipron is a non-peptide small molecule drug that is easy to manufacture and can be packaged as a pill.Although its price has not been determined, it is probably much cheaper than existing polypeptide weight loss drugs.Sean Wharton, a physician at McMaster University in Canada who led the Phase II clinical trial, believes Orforglipron is a game changer.
Orforglipron could bring pharmacological weight management to a wider population, while retatrutide could provide unprecedented levels of weight loss.
Using the highest dose of retatrutide, participants lost an average of 24.2 percent of their weight over the course of 11 months of treatment, while currently approved drugs lost 15-20 percent of their weight over a similar period of time.What's more, obese patients who received high doses of reatrutide lost more than 5 percent of their weight.
Beverly Tchang, an obesity medicine specialist at Will Cornell Medical Center in the United States, points out that retatrutide can interact with three receptors that determine appetite, which may be why it is so effective.Wegovy interacts with one receptor, and Mounjaro interacts with both receptors.
Both Wegovy and Mounjaro can have unpleasant side effects, such as nausea and vomiting.The same is true of Orforglipron and Reatrutide.But developers aren't too worried about these possible side effects, and users can mitigate them by slowly increasing the dosage used.
People who use these medications for weight loss are likely to slowly regain their weight if they stop taking them.Wharton explains that because of the biological basis of obesity, the human brain seems to have a set value for how much fat the body stores, and that drugs can only mask that set value, not change it completely."Does it make sure you don't get your weight back after stopping the medication?This idea does not fit the biological basis of the human body.”Wharton
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