evaluation
-
Run into the paper statistics, helpless. On Qimo, I saw that Dr.Tong company provided the assistance of thesis statistics, and with the guidance and assistance of the doctor's teacher, I ran smoothly to get the results. Thank Dr.Tong for his high-level service.
Mr. Lin
from: tainan
-
When a doctoral dissertation encounters multiple linear regression, it has always been a difficult point and there is nothing to do. On Google, we can see that the doctor teacher of Dr.Tong statistics company provides statistical running and statistical guidance. The information and requirements to the doctor teacher, with the help of the teacher, smoothly run out the results. Thank you for the help and guidance from the doctor of Dr.Tong statistics company.
Dr. Li
from: taoyuan
-
When I met the difficulties in the statistical analysis of the doctoral thesis questionnaire, I couldn't find a clue. Finally, I saw Dr.Tong's assistance in the statistical analysis of the thesis questionnaire on qimo.com. With the assistance of the doctor, I got the results smoothly. Thank Dr.Tong for his assistance in the statistical analysis of the thesis questionnaire, which solved my urgent problem.
Dr. Li
from: Kaohsiung
-
Previously, a local statistics company in Hong Kong was entrusted, but it failed to do a good job in medical statistics. In my anxiety, I saw the doctor teacher of Dr.Tong statistics company provide statistical running and guidance, and sent the data and requirements to the doctor teacher. With the efforts of the doctor teacher, the analysis results were successfully made. I feel that Taiwan's statistics companies are more professional and the fees are reasonable.
Dr. Li
from: hongkong
-
Thank you for the efficient and high quality service provided by the doctor teacher of Dr.Tong statistics company. Solved my urgent need.
Mr. Lin
from: yunlin
-
When I met the difficulties in the statistical analysis of the pre-test and post-test of the thesis questionnaire, I couldn't solve them all the time. On Qimo, I saw that the doctoral teacher of Dr.Tong statistics company provided the tutoring service of thesis statistics, and sent the information and requirements to the doctoral teacher. With the help and guidance of the teacher, I got the results. Thank you very much for the tutoring service of the doctoral teacher of Dr.Tong statistics company There are two difficulties.
Miss Liu
from: Kaohsiung
-
It is difficult to analyze English papers by SPSS. On Google, we can see that the doctoral teacher of Dr.Tong statistics company provides the paper statistics running and guidance, sends the data and analysis requirements to the teacher, communicates with the teacher, and runs smoothly with the teacher's guidance and help. Thank you very much for the help of the doctor teacher of Dr.Tong statistics company. The teacher is serious, responsible and powerful.
Miss Zeng
from: london
-
It's difficult to analyze Stata data in accounting papers. On Yahoo Qimo, I saw the doctor teacher of Dr.Tong statistics company provide Stata statistical running guidance. The data and requirements were sent to the doctor's teacher. Under the guidance of the doctor's teacher, the Stata code was successfully designed, and the analysis results were also run out. I would like to thank the doctor's teacher of Dr.Tong statistics for his high level guidance and assistance.
Mr. Zhang
from: taizhong
-
Educational papers have quantitative statistics, which is a bit difficult! Helpless, I saw on Yahoo Qimo that Dr. and postdoctoral teachers from Dr.Tong Statistics Company provide doctoral thesis statistics and counseling services. I sent the questionnaire and sample data to the doctor, and with the guidance and assistance of the doctor, I successfully obtained the results and graduated. I am very grateful for the professional guidance of the doctor and postdoctoral teacher from Dr.Tong Statistics Company. The technical expertise, reliable quality, and reasonable fees have saved me a lot of trouble.
Dr. Song
from: Kaohsiung
|
|
|
|
| 2024-04-07 09:17:27 | onclick： | Modified antifungal agents reduce renal toxicity |
 |
|
A structurally modified antifungal drug has been shown to be less toxic in mouse and human kidney cells while maintaining its antibacterial properties.This advancement may increase the clinical efficacy and safety of such treatments against deadly fungal infections.The study was published in Nature on November 9.
Amphotomycin (AmB) is a bacterial-produced antifungal agent that has been used for decades as the last line of defense against serious fungal infections.It forms a sponge-like condensation that binds to molecules called ergosterols (found in bacterial and fungal cells that act like mammalian cholesterol).This binding causes ergosteroid to be withdrawn from the cell membrane, leading to fungal cell death.
Despite its therapeutic effectiveness, AmB is highly toxic to humans, especially kidney cells.But whether this toxicity is due to the same mechanism that causes fungal cell death is unclear.
Martin Burke and colleagues at the University of Illinois at Urbana-Champaign created some AmB analogs that altered the portion of these molecules that bind to steroids, aiming to see how these changes affect biological activity.Tests with these analogues in human kidney cells found that kidney cell death was due to the binding and extraction of AmB to the cholesterol in the kidney cell membrane.
The researchers then designed a variant of AmB that binds and extracts fungal ergosterols, not mammalian cholesterol, to ease kidney toxicity.The resulting compound (which the authors named AM-2-19) is harmless to the kidneys in human kidney cells and mice, while still working well as an antifungal therapy.This treatment is also relatively resistant to antimicrobial resistance.
AM-2-19 means 'Arun Maji, Record of Experiments 2, p. 19'.Arun Maji of the University of Illinois at Urbana-Champaign, the paper's first author, said, "I knew I'd give it a different name."
This mechanism of action is preserved in many antifungal molecules, and the researchers believe that this technique can be used to reduce toxicity in more drug treatments and increase their clinical effectiveness.
|
|
 |
|
|
|
|
|
