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2024-01-19 12:47:48 | onclick: | Latest Research Ideas for Large-Size Bone Repair Materials

Recently, Shao Longquan, a professor at Southern Medical University Stomatology Hospital, pointed out that the new research provides new ideas for the design of large-scale bone repair materials.The review was published in Advanced Health Materials.
The review shows that the repair of large jaw and other bone defects is still a medical problem.Endochondral osteogenesis (ECO) process based on cartilage template is the key to repairing large bone defects.Hydrogels have a unique highly hydrated 3D polymerization network, which can be designed as bionic materials with physical and chemical properties close to cartilage substrates, thereby promoting ECO.
The preparation methods of various hydrogels with ECO promotion were introduced in this paper. The physicochemical properties of hydrogels, such as mechanical properties, surface morphology and chemical composition, were summarized.Finally, the molecular mechanisms of these physical and chemical properties regulating ECO are summarized in detail.This review provides new ideas for the design of large size bone repair materials.
The reporter learned that Shao Longquan team has long been committed to the research and development of new biological materials that promote bone formation and vascularization, and deeply explore the molecular mechanism of material regulation and tissue regeneration.

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