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| 2023-11-17 11:37:32 | onclick： | Scientists reveal theoretical basis for "genetic transboundary regulation" |
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Sun Fei and Zhang Chenyu from the School of Life Sciences, Nanjing University published a paper in the journal Cell Research, revealing the potential molecular mechanism of SID-1 transmembrane family protein low pH nucleic acid transport.
In 2006, American scientists Andrew Fire and Craig Mello won the Nobel Prize in Physiology or Medicine for their work on RNA interference.Today, the technology is increasingly used to regulate the expression of human genes.
In mammalian cells, SIDT2 is involved in intracellular DNA/RNA autophagy and transports lysosomal nucleic acid to cytoplasm, triggering innate immune response, and SIDT1 directly mediates miRNA absorption.However, the molecular mechanisms of SID-1 transmembrane family proteins SIDT1 and SIDT2 mediated the absorption of heterologous small RNAs are still unclear, especially at low pH.
The research team first solved the difficulties of membrane protein expression purification and the serious orientation advantage in the preparation of frozen samples.Through structural analysis, the researchers found that SIDT1 and SIDT2 were highly similar in structure, suggesting that they may have similar biological functions.In addition, the researchers further explored the molecular mechanisms of SIDT1 and SIDT2 mediated small RNA transport.
The structure of transmembrane family proteins SIDT1 and SIDT2 in mammalian cells was analyzed. The molecular characteristics of pH-dependent binding and oligomerization of SIDT1 and SIDT2 with RNA were first proposed.Therefore, this study provides the molecular basis for SID-1 transmembrane family protein in nucleic acid transport, and also provides the theoretical basis for gene transboundary regulation.
Sun Fei and Zhu Jian, researchers at the Institute of Biophysics, Chinese Academy of Sciences, co-authors Xiaoyun and Zhang Chenyu, professors at the School of Life Sciences, Nanjing University.Zheng Le and Yang Tingting, Ph.D. students from School of Life Sciences, Nanjing University; Guo Aerospace, Ph.D. students from Institute of Biophysics, Chinese Academy of Sciences; and Lu Yuchi, Ph.D. students from Institute of Immunochemistry, Shanghai University of Science and Technology.The research has been funded by projects such as the National Key R&D Program and the National Natural Science Foundation.
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