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| 2023-09-22 09:57:49 | onclick： | Advances in Bionic Artificial Transmembrane Signal Transduction |
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Recently, Professor Bao Chunyan of the School of Chemistry and Molecular Engineering of East China University of Technology and Nobel Prize Scientists Joint Research Center of Feilinga designed and synthesized a novel artificial transmembrane signal transduction receptor molecule.The results were published in the Journal of Chemistry of America under the title of Fully Synthetic Artificial Transmembrane Receptors for Switching Signal Transduction by Folding/Unfolding Conformation Changes.
The signal transduction protein on cell membrane can help cells realize signal transduction inside and outside cell and regulate cell activity. It plays a key role in cell growth, proliferation and metabolism.Unlike ion channel proteins, transmembrane transduction is accomplished by recognition, transmembrane conformational transformation, activation and downstream reaction of extracellular signal molecules.In view of the complexity and low abundance of signal transduction receptor protein in natural system, artificial signal transduction system is not only helpful to understand the working mechanism of natural signal transduction protein.
In this paper, we propose a novel fully synthetic artificial signal transduction molecule based on folding conformational modification, which is similar to the transmembrane signal transmembrane signal transduction.The designed receptor molecule has three functional modules, including a cholic acid head group with lipid membrane anchoring function, a transmembrane helical fold and a catalytic activation tail group.Lipophilic structural characteristics give artificial receptor molecules the ability to insert membranes efficiently. Cholic acid anchoring causes the folded molecules to restrict their tail group from entering the liposome cavity.After the signal Zn2+ is added, the folded body is decomposed, and the extended molecular length causes the tail to enter the internal cavity and perform catalytic tasks to turn on the signal transduction ("ON" state).Further introduction of tri(2-aminoethyl)amine(TAEA) to compete Zn2+ can restore the folded state of the receptor molecule and turn off the signal transduction ("OFF") state.The controllable artificial signal transduction is realized by simple metal complexation and deconjugation, which provides a new molecular paradigm for the development of a new artificial transmembrane signal transduction system.
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