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from: Kaohsiung
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from: taizhong
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from: Kaohsiung
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| 2023-09-22 09:49:33 | onclick： | T-cells can become more aggressive anti-cancer "fighters" after decompression. |
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Even for the immune "fighter" of killer T cells, searching for and destroying the enemy, cancer cells, all day long can be exhausting.Scientists at the Solk Research Institute in the U.S. found a link between killing T-cell depletion and sympathetic stress in mice and human tissue samples.
The team found that beta blockers, a class of drugs already used to control blood pressure and heart rate, inhibit the interaction between killer T cells and sympathetic stress hormones to produce killer T cells and fight tumors more effectively.
The new study establishes a new link between sympathetic stress responses and immune system responses to cancer, and demonstrates the benefits of pairing beta blockers with existing immunotherapy to improve cancer treatment by enhancing killer T cells.
Researchers say immunotherapy has revolutionized the way cancer patients are treated, but it is still ineffective in many patients, and the new findings have opened up new avenues for revitalizing T cells in tumors.
The sympathetic nervous system mediates the body's stress response, also known as the "fight or flight" response.However, little is known about how nerves regulate immune responses to infection or cancer.
The researchers studied the effects of sympathetic nerves on killer T cells by using cancer and chronic disease models in mice and human tissue samples.They found that sympathetic nerves produce norepinephrine, which binds to T cells through ADRB1 receptors.Exhausted killer T cells express more ADRB1 receptors, enabling T cells to "listen" to the neurotransmit norepinephrine.Surprisingly, ADRB1 receptors in turn inhibit T cell function, making them worse at fighting cancer.
Thus, the researchers tested how to inhibit the interaction between noradrenaline and ADRB1 to prevent killer T-cell depletion.Next, they will study more samples of human cancer tissue to enrich the weighty discovery.
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