evaluation
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Run into the paper statistics, helpless. On Qimo, I saw that Dr.Tong company provided the assistance of thesis statistics, and with the guidance and assistance of the doctor's teacher, I ran smoothly to get the results. Thank Dr.Tong for his high-level service.
Mr. Lin
from: tainan
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Dr. Li
from: taoyuan
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Dr. Li
from: Kaohsiung
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from: hongkong
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Mr. Lin
from: yunlin
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When I met the difficulties in the statistical analysis of the pre-test and post-test of the thesis questionnaire, I couldn't solve them all the time. On Qimo, I saw that the doctoral teacher of Dr.Tong statistics company provided the tutoring service of thesis statistics, and sent the information and requirements to the doctoral teacher. With the help and guidance of the teacher, I got the results. Thank you very much for the tutoring service of the doctoral teacher of Dr.Tong statistics company There are two difficulties.
Miss Liu
from: Kaohsiung
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from: london
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Mr. Zhang
from: taizhong
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Dr. Song
from: Kaohsiung
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| 2023-09-16 04:48:53 | onclick： | Chinese Scientists Reveal New Mechanisms for Pulmonary Fibrosis |
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On September 4, Ji Guangjue, Institute of Biophysics, CAS, published a research paper in the internationally renowned journal "Stem Cell Research & Therapy" to reveal the role and mechanism of human embryonic stem cell exosomes in pulmonary fibrosis.
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and irreversible lung disease characterized by pulmonary fibrosis and impaired lung function, which eventually leads to respiratory failure.Many studies have found that stem cell exosomes have great potential in the intervention of fibrosis.Among them, MSC-Exos is the most widely studied exosomes, which are rich in bioactive substances, which can reduce inflammation, inhibit fibrous scar formation, and promote the regeneration of damaged tissue.It was found that human embryonic stem cell exosomes (hESC-Exos) were superior to MSC-Exos in regulating damage repair.However, the intervention effect of hESC-Exos in pulmonary fibrosis has not been reported.
This study reports for the first time the significant effect of hESC-Exos in the treatment and prevention of pulmonary fibrosis and elucidates its molecular mechanism, providing a new perspective on drug development for fibrosis-related diseases.The results showed that hESC-Exos injection could significantly reduce inflammation, remove collagen deposition, repair damaged alveolar structure, increase pulmonary blood flow and improve lung function in mice.In terms of mechanism, it was found that hESC-Exos carries a high abundance of miR-17-5p, which regulates the expression of thrombospondin-2 (Thbs2) and inhibits the occurrence and progression of pulmonary fibrosis.
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