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from: tainan
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from: Kaohsiung
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from: hongkong
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from: yunlin
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from: Kaohsiung
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from: taizhong
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Dr. Song
from: Kaohsiung
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| 2023-09-07 06:28:51 | onclick： | New Progress in Pig Delta Coronavirus Research |
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Recently, Huang Xiaobo, a professor of pig disease research center at Sichuan Agricultural University, published a research paper in the International Journal of Biological Macromolecules.For the first time, the team systematically identified the T-cell epitopes of swine 冠状病毒 coronavirus (PDCoV) structural protein and evaluated the animal immunity.
Pig Delta Coronavirus (PDCoV), also known as pig Delta Coronavirus or pig Ding-type Coronavirus, has been reported in the Americas, Asia and other pig breeding countries. The virus mainly causes symptoms such as vomiting, diarrhea and death.At the same time, the cross-species spread of PDCoV and potential public safety risks have attracted global attention.So far, PDCoV's pathogenic mechanism, immune mechanism and vaccine development have lagged behind, among which PDCoV's studies on T cell epitopes have not been reported.
In this study, the epitopes of SLA-1 restricted T cells of PDCoV were predicted by bioinformatics, and 5 epitopes of PDCoV infected piglets were identified by ELISPOT, ICS and qPCR.The T cell epitopes identified in this study are of great academic and application value in analyzing the immune mechanism of PDCoV and designing a new vaccine.
Sichuan Agricultural University 2020 Master's Degree of Literature and Art, 2020 Doctor's Degree of Chen Yao and 2022 Master's Degree of Yang Junpeng are co-authors of the paper, and Huang Xiaobo is the author of the paper newsletter.The research was funded by the National Natural Science Foundation, Sichuan International Science and Technology Innovation Cooperation Project, Sichuan Science and Technology Project and Yunnan Science and Technology Department.
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