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| 2022-02-18 14:18:48 | onclick： | Australian study found that Chlamydia pneumoniae may induce Alzheimer's disease |
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A study conducted by Griffith University in Australia found that Chlamydia pneumoniae can invade the brain through the nasal cavity, inducing some pathogenic factors that may lead to Alzheimer's disease. Relevant papers have been published in the British Journal scientific report.
Jenny Eckberg, an associate professor at the Menzies Institute of health at the University of Griffith who participated in the study, said they had previously found that several microorganisms, including Chlamydia pneumoniae, can quickly enter the central nervous system through the peripheral nerve between the nasal cavity and the brain within 24 hours. Chlamydia pneumoniae is known to cause respiratory diseases, but researchers also want to know whether it will damage the central nervous system once it invades the brain.
Through mouse experiments, the research team found that after Chlamydia pneumoniae invaded the central nervous system, mouse brain cells would respond within a few days and produce β Amyloid deposits, which are one of the main pathogenic factors of Alzheimer's disease. In the following weeks, many gene pathways known to be related to Alzheimer's disease were also significantly activated.
This study also found that when Chlamydia pneumoniae invades the olfactory nerve, it will infect glial cells, which may play an auxiliary role in the survival and transmission of Chlamydia pneumoniae in the nervous system.
Although the study was conducted in mice, the researchers believe that the nerves of humans and mice are very similar and can be infected with Chlamydia pneumoniae, so the results may also apply to humans.
Eckberg said the study provides an idea for the treatment of Alzheimer's disease. At present, they are working with scientific research institutions to find drugs that are expected to help glial cells kill Chlamydia pneumoniae that has entered the brain. Researchers at the Queensland Institute of technology are developing an anti Chlamydia pneumoniae vaccine to reduce its ability to invade the brain.
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