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| 2021-12-12 11:56:31 | onclick： | Precise scissor technology for gene editing |
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Several latest research results are displayed on the popular science platform on the first floor of the Institute of stem cell and regenerative medicine innovation, Chinese Academy of Sciences. In stem cell drugs, regenerative medicine, decryption aging and other projects, several small kits seem thin, but they have important value and significance. "This is a kit for rapid detection of COVID-19. Compared with traditional detection methods, it does not rely on complex instruments and equipment. It is more convenient, simpler and faster. We have done nucleic acid testing, specialized sampling personnel to collect swabs for the tested people, and then professional test personnel to use special equipment for testing." Li Tianda, associate researcher in charge of the popular science platform, said, "this new kit does not need to rely on special testing equipment and can greatly improve the testing speed. This reagent is expected to be made into a pregnancy test strip in the future, so as to realize household timely testing."
This reagent was successfully developed on the basis of a new gene editing tool "crispr-cas12b". Crispr-cas12b is independently developed by the scientific research team led by researcher Li Wei of the Institute. It is a gene editing tool with CRISPR system invention patent in China.
Gene editing technology is the bottom technology of life science. It is like a magic "scissors", which can not only "cut" genes, but also "repair" genes. Its discovery has not only promoted human cognition of life, but also greatly changed the research form of life science and the development of life science and technology industry.
In 2020, the Nobel Prize in chemistry was awarded to two scientists who discovered gene editing technology. Developed countries are competing to layout patents and industries related to gene editing technology. "Gene editing technology shows strong vitality in the field of life science and technology, and has very attractive application prospects in the research and development of new drugs and the treatment of genetic diseases." Li Wei explained, "industrial development is closely related to core patented technologies. If a country does not have its own gene editing technology with independent intellectual property rights, the development of related industries will be restrained."
We can continue to use "scissors" to explain why we need our own gene editing technology - each family has more than one pair of scissors. In the family toolbox, there are scissors for different situations, and better scissors also need to be replaced. "Scientists all over the world are actively developing their own 'gene scissors' and constantly updating them. The United States has granted crispr-cas9 a patent." Li Wei introduced, "Compared with other gene editing tools, CRISPR-Cas12b is more accurate and easier to deliver gene therapy drugs in the body. At the same time, it has a wider range of active temperature and acid base. This means that CRISPR-Cas12b is more stable, easy to store, and more suitable for in vitro testing. Based on this advantage, we developed the new reagent to detect COVID-19. ”
Today, this new technology is being used in a number of basic research in life sciences and the research and development of a variety of genetic drugs, and Li Wei is also leading the team to develop more genetic "scissors". "The progress of basic research in life sciences is very close to its application. In many cases, we should not only carry out basic research, but also go deep into industrial development." Li Wei has a full schedule of work every day - after the interview, he will hold a research group meeting soon. He said, "the progress of life science is closely related to life. Facing people's life and health, scientific and technological workers are duty bound."
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