Young blood anti-aging, blood after exercise contains exercise like molecules, these are similar research ideas. Many human inventions serve the lazy, and this research is also a typical service for the lazy. Man is an animal. The basic survival logic of biology is to use the least cost to obtain the best benefit. Speculation is the main logic of life. Can not move, as long as you can get the benefits of exercise, really not necessarily exercise. It is certainly desirable to extend life and inject some anti-aging molecules. However, research belongs to research, and the long-term wish is beautiful. It seems that this idea can be widely used in human beings, and it still needs to wait. However, if it really works, there can be such a research design. For example, let the young people who like exercise regularly contribute plasma, and let the elderly people with neurodegeneration use these plasma, which can not only increase the youth factor, but also increase the exercise factor. Isn't it beautiful!

Supplement a review on the movement molecule and summarize the medical value of this molecule. Note that the logic of cancer treatment is to block this molecule, but the logic here is to increase this molecule. Obviously, a prominent question is, will increasing such molecules increase the risk of cancer?

Clusterin is a molecular chaperone independent of ATP, and small molecule inhibitors are difficult to target.

The expression of clusterin is up-regulated in a variety of diseases, including cancer.

Topical application of clusterin provides the first potential for effective prevention and treatment of dry eye disease. The change of cluster element gene is a major risk factor for AD, but it is necessary to further understand the effect of cluster element on a before formulating controllable treatment strategies β Effects of generation and removal.

As a stress-induced chaperone, clusterin is up-regulated in response to tumor radiotherapy, hormone therapy and hormone therapy. It is an attractive cancer treatment target.

Antisense ogx-011 targeted clusterin has been successful in phase II clinical trials.

Although it is promising in phase II clinical trials, the combination of ogx-011 and paclitaxel failed in phase III clinical trials, and the treatment regimen may need to be further optimized.

Many people know that exercise is good for the brain. What is the reason behind the fact that exercise can promote mental and nervous system health? If we can understand the biochemical mechanism of this process, can we get the effect of improving brain function without exercise, and further imagine that we can gain the benefits of exercise without exercise, or replace the gym with tablets. Mouse experiments have proved the feasibility of this shortcut. There are indications that the experimental results in rodents are also applicable to humans.

When the plasma of well exercising mice was injected into idle mice, the sedentary mice improved their memory and reduced their encephalitis. Of course, the blood of Olympic athletes will not be injected into sofa potato house men and women, but people with mild cognitive impairment found a protein cluster element that can play a role with running mice in their plasma after six months of exercise. This protein can pass its chemical information across the blood-brain barrier and trigger anti-inflammatory processes in the brain. The findings, published in the December 8 issue of the journal Nature, provide new details on how exercise benefits the brain. The results show that liver and anticoagulant system play an important role in these effects, suggesting that similar drugs may be prepared in the future.

"The story is getting clearer and clearer," said Saul Villeda, an associate professor of anatomy at the University of California, San Francisco, when talking about the implication of multisystem participation in the impact of exercise on the brain. Villeda and his colleagues, who were not involved in the new study, previously found a protein in the plasma of exercise mice, which can revitalize neurons in the brain of aging mice. "We began to identify factors in the blood that can target different aspects of depression or pathology, and this finding really highlights the blood factors that affect brain inflammation. The word that constantly comes to my mind is' fusion, '" he said

Zurine de Miguel, an assistant professor and behavioral scientist at California State University Monterey Bay, and her colleagues at Stanford University and the health care system of the Department of Veterans Affairs in Palo Alto, first let the mouse exercise. The animals ran for 28 days, and then their plasma was transferred to house mice. Animals receiving "runner plasma" improved both learning and memory. The brain activates genes that produce proteins that promote memory and learning and shows inhibition of inflammatory response. When researchers deliberately induced brain inflammation in animals, plasma from running mice also inhibited this response.

Next, we looked at what the runner's plasma contained. They found increased levels of anticoagulant proteins, one of which is called clusterin, which helps remove cell debris. For this protein, the researchers tested the effect of stripping it from runners' plasma. Sedentary mice showed less anti-inflammatory activity after receiving non cluster plasma.

The team also found that clusterin can easily adhere to the cells that form the blood-brain barrier. When they mimicked the effects of physical activity and injected proteins into the circulation of transgenic mice with neurodegenerative diseases, the brain inflammation of these animals also decreased.

Finally, researchers want to know whether exercise can lead to the same changes in humans. They measured cluster protein levels in 20 veterans with mild cognitive impairment before and after six months of structural physical activity and found that their levels increased.

Demigel points out that in her and colleagues' study, the results of male and female mice were different. Although the anticoagulant protein profiles were similar between the sexes, women showed more variability. The hormones they produce affect anticoagulant factors, demigel said. Some female mice may be in the stage of sexual acceptance during the study, which may explain this greater difference.

This experiment shows that people are increasingly aware that the brain depends on help from the periphery. The authors say that the liver and heart are the most likely sources of cluster elements. Demigel said the results show that both organs are the source of beneficial molecules produced by physical exercise. "They all seem to be communicating with the brain," she added.

Velada said his team's "runner plasma" study on aging mice also involved the liver. This organ produces an enzyme related to the improvement of animal cognitive ability, and the enzyme in the blood of active elderly people will also increase. The liver connection "surprised us because when you think about exercise, it's usually not your concern," he said. In terms of liver connectivity, "these mechanisms begin to converge and enter a similar space."

Although physical activity is closely related to health, it is also possible to exercise excessively. There are indications that some people who often engage in high-intensity physical activity may have an increased risk of amyotrophic lateral sclerosis. "There is some information that too much exercise will damage your immune response and make you vulnerable to opportunistic infections," de Miguel said.

If these effects are confirmed in mice, how will "runner plasma" be used as a treatment? "I'm more hopeful now than when I first started my lab because it's hard to determine all these factors," verda said. "But now we have candidates, and when you have these candidates, you can start thinking about the development of small molecules," demigel said. The first step may be to test which exercise regimen can maximize the protein beneficial to the brain. Just like in mice, those who need physical exercise to improve brain vitality can simply inject a "runner's plasma" to get the benefits of runners without pain.