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| 2021-12-01 08:10:29 | onclick： | Chinese mainstream nucleic acid detection reagents can cope with Omicron mutant |
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Xu Wenbo, director of the Institute for viral disease prevention and control of the Chinese Center for Disease Control and prevention, said in Beijing on the 30th that China's mainstream nucleic acid detection reagents can cope with the input of Omicron mutant.
The joint defense and joint control mechanism of China's State Council held a news conference on the further implementation of COVID-19 vaccination on that day. Xu Wenbo made the above remarks at the press conference.
In view of whether the nucleic acid detection reagent can effectively detect the mutation of the Xu Wenbo strain, the mutation site of the mutation is mainly concentrated on the spike protein of COVID-19. The primers and probe targets of China's main nucleic acid detection reagents are relatively stable in the ORF1ab gene and N gene, and these two target areas. "Therefore, the sensitivity and specificity of China's mainstream nucleic acid detection reagents have not changed, and can cope with the input of Omicron mutant."
Xu Wenbo further said that the primers and probe target areas of nucleic acid detection kit released by China's eighth edition of New Coronavirus pneumonia prevention and control program were also shared by the China CDC virus disease prevention and control center in January 21, 2020, and were shared in the world in the two years of COVID-19's popularity. "Many kits use this target."
Meanwhile, whether the mutation of the Qian Zhaohui will affect the effectiveness of the existing anti COVID-19 drugs, the researcher of China Academy of Medical Sciences Institute of pathogenic biology said at the press conference whether the drug is affected or not, and needs further research and confirmation.
Qian Zhaohui pointed out that the existing antiviral drugs of COVID-19 mainly include neutralizing antibody drugs and small molecule drugs. Neutralizing antibody drugs inhibit virus invasion mainly by blocking the binding of spike protein to its receptor ACE2 or blocking the conformational change of spike protein, while Omicron mutant has a large number of mutations in virus spike protein.
"Based on the published literature and the structure of new crown s protein and different neutralizing antibodies, some of these mutations may affect the therapeutic effect of a considerable part of neutralizing antibody drugs, but the specific impact degree of a certain antibody needs to be verified by experiments."
Qian Zhaohui said that the main targets of existing small molecule drugs are virus replicase and protease, and the key sites of related drug binding target proteins have not mutated on Omicron, so they may have little impact on these small molecule drugs, "However, considering that there are still mutations in virus replicase and protease, whether the drug is affected still needs further research and confirmation.".
In addition, Xu Wenbo said that China has made preliminary technical reserves and Research on multiple technical routes including inactivated vaccine, protein vaccine and vector vaccine, and relevant preliminary design of some enterprises has begun.
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