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from: Kaohsiung
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| 2021-05-05 05:30:37 | onclick： | Chinese experts reveal the secret that women are more prone to Alzheimer's disease |
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Alzheimer's disease (AD) is one of the diseases that seriously threaten the health of the elderly in the world. The data show that the prevalence of the disease in women is higher than that in men. Recently, Professor Lu Jie's team of Xuanwu Hospital of Capital Medical University found that women carry a specific apolipoprotein (ApoE) ε 4) Alleles can lead to increased aggregation of specific proteins (tau protein) in the brain, which makes it more prone to disease; However, the accumulation of specific proteins in the brain of men with two specific alleles increased significantly. That's why women are more vulnerable to Alzheimer's disease.
It is reported that a certain apolipoprotein (ApoE) is known ε 4) It is one of the most risk genes of Alzheimer's disease. The abnormal aggregation of specific proteins (tau protein) caused by tau protein is one of the characteristic pathological changes of Alzheimer's disease. This study is to explore whether there are gender differences in the aggregation of specific proteins in the brain of Alzheimer's disease patients carrying different numbers of specific alleles, and then reveal the causes of gender differences.
Lu Jie said that women account for about two-thirds of the patients with Alzheimer's disease, and the gender difference in the prevalence rate is getting more and more attention. This study explains the high prevalence of Alzheimer's disease in women to a certain extent, which is of great significance for clinical diagnosis and treatment. Based on the results of this study, it is necessary to focus on the female carriers of the above specific alleles and consider specific treatment to achieve the purpose of early prevention.
According to reports, 268 patients with cognitive impairment were included in this study, which provided imaging evidence for the higher incidence of Alzheimer's disease in women than in men. The research results were published online in brain, an international top journal of Neurology, in April 2021.
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